BSRA Meetings

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British Society for Research on Ageing (BSRA) Annual Scientific Meeting

 

 

 

"Engineering a Healthy Future"

2-3 July 2009

 

The Lowry Hotel, Chapel Wharf, Salford

 

 

 

Thursday 2^nd July

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Registration and coffee will be available from 9.00am

 

10.10 - 10.20:       Welcome, Anne McArdle, Chair, BSRA.

 

 

Session 1: Psychosocial and behavioural determinants of biological ageing.

Chair Jos Bosch, University of Birmingham.

 

 

10.20 - 10.30:       Jos Bosch (University of Birmingham): Introduction; stress and socio-economic status as determinants of biological ageing

 

10.30 - 10.50:       Tarani Chandola (Whitehall study group, UCL): Job stress and low socio-economic status as determinants of metabolic ageing

 

10.50 - 11.10:       Lynn Cherkas (Kings College): Low socio-economic status and cellular aging: parsing out the effects of genes and environment

 

11.10 - 11.30:       Marie Pardon (University of Nottingham): Harmful and protective effects of stress on cognitive ageing

11.30- 12.00:        Moises Bauer (Univ Rio Grande do Sul, Brazil): Stress and immunesenescence

 

12.00 - 2.00:         Lunch and AGM and informal poster viewing.

                               (The AGM is scheduled for 1.00 - 1.30).

 

 

 

Session 2: Tissue engineering possibilities for ageing.

Chair Aphrodite Vasilaki, University of Liverpool

 

 

2.00 - 2.10:            Aphrodite Vasilaki (University of Liverpool): Introduction

 

2.10 - 2.30:            Anthony Hollander. (University of Bristol, UK): Clinical transplantation of a tissue-engineered airway

2.30 - 2.50:            John Hunt (Clinical Engineering, University of Liverpool, UK): Tissue engineering bone regeneration

2.50 - 3.10:            Patricia Murray, (Biological Sciences, University of Liverpool): Stem cell therapies for kidney disease

 

3.10 - 3.40:            Lisa Larkin (Molecular and Integrative Physiology, Biomedical Engineering, University of Michigan, U.S.A). The use of bone marrow stromal cells for engineering skeletal tissue constructs for tissue regeneration in the elderly

 

 

3.40 - 4.15:            Afternoon tea

 

4.15 - 4.45:            Mario Fraga (Cancer Epigenetics Unit, IUOPA, Spain). Epigenetics and Ageing

 

4.45 - 5.15:            Funding Q&A: Lesley Heppell BBSRC

 

5.15 - 7.00:            Wine reception and formal poster viewing and judging (please note, posters will be different on days 1 and 2)

 

 

7.30:                       Conference dinner

 

Friday 3^rd July

 

Session 3: Hormones and ageing.

Chair: Dr Matthew Hardman, University of Manchester.

 

9.00 - 9.10:            Mat Hardman (University of Manchester): Introduction

 

9.10 - 9.30:            Mat Hardman (University of Manchester): Estrogens and ageing

 

9.30 - 9.50:            Hugh Jones (Robert Hague Centre for Diabetes and Endocrinology, Barnsley): Testosterone and ageing

 

9.50 - 10.20:          Adriana Miaggi (University of Milan, Italy): IGF and ageing

 

10.20 - 10.40:        Leptin, obesity and ageing. TBA

 

10.40 -  11.15 :      Coffee break

 

 

Session 4: Selected oral presentations

Chair: Dr Carole Proctor (University of Newcastle)

 

 

11.15 - 11.30:        Elevated presentation 1

 

11.30 - 11.45:        Elevated presentation 2

 

11.45 - 12.00:        Elevated presentation 3

 

12.00 - 12.15:        Elevated presentation 4

 

A prize, sponsored by BSRA will be awarded to the best presentation in this session.

 

 

12.15 - 1.40:          Lunch, formal poster viewing and judging (please note, posters will be different on days 1 and 2)

 

 

Session 5: The ageing bladder and bowel. BBSRC & RIA sponsored session.

Chair: Dr Lesley Heppell (BSRA)

 

1.40 - 2.00:            Marcus Drake (Bristol Urological Institute): Clinical aspects of urinary incontinence.

 

2.00 - 2.20:            John Scholefield (Nottingham University): Faecal incontinence.

 

 

2.20 - 2.35:            Elevated presentation on the ageing bladder and bowel 1

 

2.35 - 2.50:            Elevated presentation on the ageing bladder and bowel 2

 

2.50 - 3.05:            Elevated presentation on the ageing bladder and bowel 3

 

3.05 - 3.20:            Elevated presentation on the ageing bladder and bowel 4

 

A prize, sponsored by BBSRC and RIA will be awarded to the best presentation in this session.

 

 

3.20 - 4.00:            Coffee

 

4.00 - 4.40:            Plenary: Mark Birch-Machin (University of Newcastle): Sunburnt DNA: how mitochondria record the effects of UV exposure and oxidative stress on aging and cancer in human skin.

 

4.40 - 5.00:     Prize giving and closing remarks.

 

The workshop will be limited to 25 participants on a first-come first-served basis.

09.00 – 10.30:	Introduction, Professor Malcolm Jackson.
10.30 – 12.30:	Laboratory-based practical sessions.
12.30 – 13.30:	Lunch and informal discussions.
13.30 – 15.30:	Laboratory-based practical sessions.
15.30 – 16.00:	Tea/Coffee
16.00 – 18.00:	Laboratory-based practical sessions.
18.00 – 18.30:	Informal discussions and departure.

The format of the day will depend upon the numbers of individuals who are registered for the Workshop, but we anticipate that the delegates will split into 3 groups and spend up to 2 hours at each of the stations listed below. Due to Health and Safety restrictions, participants will primarily be observing experienced laboratory workers undertake the methods.

Introduction. General overview by Professor Jackson on the appropriate methods available for detection of ROS activity in cells and tissues, including mitochondria (presented by Dr Van Remmen).

Station 1. Intracellular detection of ROS. Techniques will include microscopic imaging of ROS with DCFH or other reagents and HPLC to detect specific ROS products of DCFH such as DHE and the use of intracellular spin probes in cells and tissues to determine superoxide or nitric oxide activities by EPR.

Station 2. Extracellular detection of ROS. Techniques will include analysis of extracellular superoxide activity in cells and tissues using cytochrome c and the use of extracellular spin probes to determine superoxide or nitric oxide activities by EPR.

Station 3. Measurement of markers of ROS activity and adaptive responses to changes in ROS. This will include detection of protein sulphydryl, carbonyl and glutathione content in cells and tissues. Adaptive responses to ROS will include determination of redox-sensitive transcription factor activation, determination of antioxidant enzyme activities and stress protein content (protein and mRNA using QPCR).

Upon registration, we will ask individuals to register their interests in learning particular techniques. The Programme may be modified accordingly. Suggestions for any techniques which are not currently listed will also be considered at that time.

9.30	Registration and Poster set-up. Tea/coffee will be available upon arrival.
10.20 - 10.30	Professor Janet Lord. Introduction and Welcome.
10.30 - 11.10	Dr Christine Seehuus, Norwegian University of Life Sciences. Bees as a model for social aspects of ageing.
11.10 - 11.50	Lynne Cox, University of Oxford. Modelling genomic instability of Werner's syndrome in the fruit fly.
11.50 - 12.30	Holly Van Remmen, University of Texas Health Science Center, San Antonio, USA. The role of superoxide - induced oxidative stress and mitochondria in age-related muscle atrophy.
12.30 - 13.00	Two presentations selected from submitted abstracts.
13.00 - 14.30	Lunch, Poster viewing and AGM
14.30 - 15.00	Two presentations selected from submitted abstracts
15.00 - 15.40	David Wong. St Paul's Eye Hospital, Liverpool. Surgery for macular degeneration: a proof of principle or a practical treatment?
15.40 - 16.20	Martin Bennett. Addenbrooke's Centre for Clinical Investigation Ageing and atherosclerosis.
16.20 - 16.45	Coffee
16.45 - 17.30	Nick Lane. Writer and Honorary Senior Research Fellow, University College London. Life, Death and Mitochondria
17.30 - 18.30	Lord Cohen Medal lecture. Professor Raymond Tallis. University of Manchester. Ageing Research: Makropoulitan and other Reflections

Presentations will take place in the Gallery and posters displays and lunch will be in the Chapel. The AGM will take place in the Gallery.

Evening: Social at ASK Italian Restaurant (5 minute walk from Lime Street Train Station).

Ageing Mind Ageing Body

For those that wish to stay over night, accomodation has been reserved at St Anne's college - these rooms will be allocated on a first come first served basis- the rooms should be booked via Dr Lynne Cox.

Poster boards will be 2m high and 1m wide

10:00-10:30 Registration, coffee and poster set up

10:30-10.35 Introduction and Welcome - Prof. J M Lord

10:35-11:05 Professor Ian Deary (Edinburgh University)

Childhood IQ and Healthy Ageing

11:05-11:35 Professor Gordon Wilcock (Bristol University)

Unhealthy ageing - Alzheimers disease

11.35-12.00 Professor Hugh Perry (Southampton University)

Impact of systemic inflammation on the inflamed brain

12.05-2.35 Two short presentations selected from poster submissions

12:35-2.00 Lunch & Poster Session

2.00-2:15 BSRA Annual General Meeting

2:15-2:45 Two short presentations selected from poster submissions

2.45-3.15 Dr Colin Watts ( Cambridge University)

Repairing the ageing brain - potential for stem cell therapy

3.15-3.45 Professor Michael Rowan (Trinity College Dublin)

Targeting Alzheimer's disease - amyloid ß-protein disruption of synaptic plasticity

3:45-4.15 Tea and poster session

4:15-5:15 LORD COHEN MEDAL LECTURE: Professor Tom Kirkwood (Newcastle University)

TBA

5:15 Prizes for Best poster and Oral presentation

5.45-6.30 Evening Keynote Speaker: Professor Doug Carroll (Birmingham University)

Happiness in the Third Age of Man

19.00 Social with meal at nearby restaurant - all welcome